Title of article
Asymmetric synthesis of the C1–C6 portion of the psymberin using an Evans chiral auxiliary
Author/Authors
Pal، نويسنده , , Ashutosh and Peng، نويسنده , , Zhenghong and Schuber Jr.، نويسنده , , Paul T. and Bhanu Prasad، نويسنده , , Basvoju A. and Bornmann، نويسنده , , William G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
5555
To page
5557
Abstract
The C1–C6 region of the potent cytotoxic agent psymberin has been synthesized. The key transformations of the synthesis are an auxiliary-controlled addition of a Sn(II)-glycolate enolate to an aldehyde to yield the anti-aldol product and transforming the primary alcohol into a terminal olefin utilizing organoselenium chemistry.
Keywords
psymberin , auxiliary , Pederin , Synthesis , Stereochemical , Chiral
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885645
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