Author/Authors :
Safari، Javad نويسنده Laboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, P.O. Box: 87317-51167, Kashan, I , , Zarnegar، Zohre نويسنده Laboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, P.O. Box: 87317-51167, Kashan, , , seha، Simin نويسنده Laboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, P.O. Box: 87317-51167, Kashan, I.R., Iran , , Akbari، Zahra نويسنده Department of Dermatology, Razi hospital, Tehran University of Medical Sciences, Tehran ,
Abstract :
A simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on silica gel (SiO2-OSbCl2) as a catalyst in ethanol at moderate temperature. Operational simplicity, practicability and applicability to various substrates make this method an interesting alternative to previously applied procedures. From the environmental standpoint, this eco-friendly green catalyst is stable, highly active, easy to prepare and handle.
