Title of article :
Green and diastereoselective synthesis of trans-3-(5-methylisoxazol-3-yl)-3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazines
Author/Authors :
Shafiee Ardestani، Mehdi نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences,Tehran, Iran , , Khosropour، Ahmad Reza نويسنده , , Mohammadpoor-Baltork، Iraj نويسنده , , Moghadam، Majid نويسنده Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan, 81746-7344, Iran , , Tangestaninejad، Shahram نويسنده , , Mirkhani، Valiollah نويسنده Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan, 81746-7344, Iran , , Khavasi، Hamid Reza نويسنده Department of Chemistry, Shahid Beheshti University, Evin, Tehran 1983963113, Iran ,
Abstract :
Reaction between aromatic aldehydes and 3–methyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-SiO2/HClO4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol derivatives in high yields.
