Correlation between women age and oocyte quality, embryo formation and

It is documented that there is a decline in female fertility as a function of age. To estimate the effect of women age on assisted reproductive technology (ART) outcomes, a total of 1560 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles wereinitiated in different age-groups women. (Group 1:age ?25, Group 2: age between 26-30 , Group 3: age between 31-35, Group 4: age between 36-40, Group 5: age > 40). Patient’s data and pregnancy outcomes were ascertained by records review and face-to-face follow-up. Age, number of retrieved oocytes and matured oocytes, types of ART procedures, number of fertilized oocytes, zygote and embryo scores, as well as, pregnancy and delivery rates were evaluated. The results showed a significantly negative correlation between age of patients and the number of oocytes retrieved (P < 0.01), mature oocytes (P < 0.001), and fertilized oocytes (P < 0.01) in five age- groups. Wefound no significantly differences in the number of mature oocytes in the 26–30 age group with the women who aged between 31 and 35 (P=0.066). The zygote and embryo scores only showed a significant negative correlation with age in women more than 40 years of age (P?0.01 for each). However, a statistically negative correlation was found between the age of women with clinical pregnancy and delivery rates (P=0.031 and P=0.006, respectively). No striking differences found in pregnancy rate between IVF and ICSI procedures (P=0.095 and P=0.117, respectively). Our findings recommend that the age-related decline in female fertility by effect on oocyte and embryo quality. The women age negatively influence outcomeof assisted reproductive technology treatment.