Title of article
First total synthesis and structure confirmation of diacetylenic polyol (+)-oploxyne B
Author/Authors
Srihari، نويسنده , , P. and Sathish Reddy، نويسنده , , A. and Yadav، نويسنده , , J.S. and Yedlapudi، نويسنده , , D. and Kalivendi، نويسنده , , Shasi V. Kalivendi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
5616
To page
5618
Abstract
The first total synthesis of the natural product (+)-oploxyne B is achieved. The synthesis has led to the confirmation of absolute stereochemistry of the natural product. The natural product displayed cytotoxic activity with IC50 values varying from 16 to 53 μM in four cancer cell lines tested.
Keywords
Cadiot–Chodkiewicz coupling , Bromo acetylene , Ohira–Bestmann , Polyacetylene , acetonide
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886296
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