Title of article
Synthesis of a bipyridine-derived achiral thiourea trifluoromethanesulfonic acid salt and its application as an additive in organocatalytic asymmetric reactions
Author/Authors
Demir، نويسنده , , Ayhan S?tk? and Basceken، نويسنده , , Sinan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
5677
To page
5681
Abstract
The host–guest complex of a proline–thiourea bipyridine trifluoromethanesulfonic acid salt can catalyze organocatalytic asymmetric reactions such as aldol, Michael, and Mannich in polar protic medium with high stereoselectivities. The privileged bipyridine backbone and the thiourea motif are essential to the activity and enantioselectivity through hydrogen bonding interactions.
Keywords
Host–guest complex , Asymmetric aldol reaction , Enantioselective Michael reaction , Proline–thiourea interaction , Asymmetric Mannich reaction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886316
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