Title of article :
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Author/Authors :
Huestis، نويسنده , , Malcolm P. and Liu، نويسنده , , Wendy and Volgraf، نويسنده , , Matthew and Purkey، نويسنده , , Hans E. and Yu، نويسنده , , Christine and Wang، نويسنده , , Weiru and Smith، نويسنده , , Darin and Vigers، نويسنده , , Guy and Dutcher، نويسنده , , Darrin and Hunt، نويسنده , , Kevin W. and Siu، نويسنده , , Michael، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
6
From page :
5802
To page :
5807
Abstract :
A series of unique bicyclic aminooxazolines were synthesized and found to exhibit micromolar inhibition of β-secretase-1 (BACE-1). The aminooxazolines were procured by an intramolecular diethylaminosulfur trifluoride (DAST)-mediated ring closure of a benzylic urea onto a secondary alcohol.
Keywords :
Aminooxazolines , ?-Secretase , Oxazolines , Alzheimer’s Disease , BACE
Journal title :
Tetrahedron Letters
Serial Year :
2013
Journal title :
Tetrahedron Letters
Record number :
1886365
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1886365
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