Author/Authors :
Pore، نويسنده , , D.M. and Patil، نويسنده , , P.B. and Gaikwad، نويسنده , , D.S. and Hegade، نويسنده , , P.G. and Patil، نويسنده , , J.D. and Undale، نويسنده , , K.A.، نويسنده ,
Abstract :
A catalyst-free multicomponent reaction (MCR) capable of affording a wide range of novel spiro pyranopyrazole derivatives from pyrazolone in situ formed from acetylenic esters with hydrazine hydrate at room temperature with isatin and malononitrile is reported. A plausible mechanism is suggested. Catalyst-free conditions along with green solvent system make the process ecofriendly as well as economical. Simple reaction conditions and easy work-up procedure that resulted into simple isolation and purification of products by non-chromatographic methods, that is, by simple recrystallization from methanol as well as novelty are the significant advantages of the present protocol.
Keywords :
Knoevenagel condensation , multicomponent , Economical , catalyst-free , Spiro pyranopyrazoles
