Title of article
Catalyst free Michael addition of 3-methyl-2-pyrazolin-5-one to β-nitrostyrenes ‘on water’: a green protocol for facile synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol
Author/Authors
Meshram، نويسنده , , H.M. and Satish Kumar، نويسنده , , Nandigama and Nanubolu، نويسنده , , Jagadeesh Babu and Chandrasekhara Rao، نويسنده , , L. and Nageswara Rao، نويسنده , , N.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5941
To page
5944
Abstract
A highly efficient and green protocol has been developed for the synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol via Michael addition of 3-methyl-2-pyrazolin-5-one with β-nitrostyrenes under catalyst free conditions on aqueous medium. A series of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ols have been synthesized with good to excellent yield. C-alkylated product was observed exclusively with 3-methyl-2-pyrazolin-5-one without formation of N-alkylated product.
Keywords
?-Nitrostyrene , Pyrazole , 3-Methyl-2-pyrazolin-5-one , Michael addition , water
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886426
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