Author/Authors :
Wang، نويسنده , , Le and Wang، نويسنده , , Yan and Guo، نويسنده , , Fangxu and Zheng، نويسنده , , Yue and Bhadury، نويسنده , , Pinaki S. and Sun، نويسنده , , Zhihua، نويسنده ,
Abstract :
A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.
Keywords :
1 , 3-Disubstituted benzenes , Formylation , Regioselective lithiation
