Title of article
Counterion effects in the preparation of aldehyde–bisulfite adducts
Author/Authors
Kissane، نويسنده , , Marie G. and Frank، نويسنده , , Scott A. and Rener، نويسنده , , Gregory A. and Ley، نويسنده , , Christopher P. and Alt، نويسنده , , Charles A. and Stroud، نويسنده , , Paul A. and Vaid، نويسنده , , Radhe K. and Boini، نويسنده , , Sathish K. and McKee، نويسنده , , Laura A. and Vicenzi، نويسنده , , Jeffrey T. and Stephenson، نويسنده , , Gregory A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
6587
To page
6591
Abstract
The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the extension of the scope of this study to include an investigation into the solid state properties of a range of sodium and potassium bisulfite adducts of commonly encountered aldehydes is discussed.
Keywords
Evacetrapib , Solid state properties , Aldehyde–bisulfite adduct , Rosenmund reduction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886791
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