Author/Authors :
Araْjo Cordeiro، نويسنده , , Kelly C.F. and Rezende، نويسنده , , Kênnia R. and Vaz، نويسنده , , Boniek G. and Romمo، نويسنده , , Wanderson and Liمo، نويسنده , , Luciano M. and de Souza Gil، نويسنده , , Eric and de Oliveira، نويسنده , , Valéria، نويسنده ,
Abstract :
This Letter describes glycosylation of 4-Nerolidylcatechol (4-NRC) the major secondary metabolite from Pothomorphe peltata and Pothomorphe umbellata showing remarkable antioxidant, antimalarial, anti-inflammatory, and anti-HIV activities. One step biosynthesis was catalyzed by Cunninghamella echinulata ATCC 9245 and the reaction was undertaken in PDSM medium at 27 °C, 200 rpm for 96 h. After purification by silica gel flash column chromatography the 4-NRC β-glycoside was identified by ultrahigh resolution mass spectrometry and 1H NMR. The antioxidant activity was evaluated by differential pulse voltammetry.
Keywords :
4-Nerolidylcatechol , 4NRC-?-glycoside , glycosylation , CUNNINGHAMELLA
