Title of article :
A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
Author/Authors :
Wang، نويسنده , , Gan and James، نويسنده , , Clint A. and Meanwell، نويسنده , , Nicholas A. and Hamann، نويسنده , , Lawrence G. and Belema، نويسنده , , Makonen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A stereoselective and scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid (3a) is described. Key to the success of the devised route was the realization that the stereoselectivity of a cyclopropanation step could be controlled by the composition of the functional group at C-α.
Keywords :
Epimerization , Cyclopropanation , equilibration , methanoproline , Oxidative decarboxylation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
