Author/Authors :
Santana، نويسنده , , Amanda S. and Carvalho، نويسنده , , Diego B. and Cassemiro، نويسنده , , Nadla S. and Viana، نويسنده , , Luiz H. and Hurtado، نويسنده , , Gabriela R. and Amaral، نويسنده , , Marcos S. and Kassab، نويسنده , , Najla M. and Guerrero Jr.، نويسنده , , Palimécio G. and Barbosa، نويسنده , , Sandro L. and Dabdoub، نويسنده , , Miguel J. and Baroni، نويسنده , , Adriano C.M.، نويسنده ,
Abstract :
A simple synthesis of 3-iodothiophenes was demonstrated using a wide range of (Z)-thioenynes. The key step in the iodocyclofunctionalization was the selective reduction of the triple bond in (Z)-thioenynes by the addition of iodine as an electrophilic agent. The 3-iodothiophenes were obtained in good to excellent yields of 61–92%. The 3-iodothiophenes were used as substrates in Sonogashira cross-coupling reactions to obtain thiophene acetylenes.
Keywords :
Sonogashira cross coupling , 3-Iodothiophenes , (Z)-Thiobutenynes , iodocyclization
