Author/Authors :
Ma، نويسنده , , Ke and Wang، نويسنده , , Jun-Song and Luo، نويسنده , , Jun and Yang، نويسنده , , Ming-Hua and Yao، نويسنده , , He-Quan and Sun، نويسنده , , Hong-Bin and Kong، نويسنده , , Ling-Yi، نويسنده ,
Abstract :
Two novel dimeric monoterpene indole alkaloids, bistabercarpamines A (1) and B (2) possessing unprecedented bis-vobasinyl-chippiine-type skeleton, were isolated from the leaves of Tabernaemontana corymbosa. The structures were elucidated on the basis of spectroscopic data, and the absolute configurations of these isolates were determined by CD excition chirality method. Bistabercarpamine A (1) exhibited moderate cell growth inhibitory activity against HepG-2 cells with IC50 of 38.14 ± 1.1 μM.
Keywords :
Vobasinyl-chippiine-type bisindole alkaloid , cytotoxic activity , Bistabercarpamines A and B , Tabernaemontana corymbosa
