Title of article
NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts
Author/Authors
Luo، نويسنده , , Laichun and Meng، نويسنده , , Lanlan and Sun، نويسنده , , Qi-Wei Ge، نويسنده , , Zemei and Li، نويسنده , , Runtao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
259
To page
263
Abstract
A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN2 alkylation/Thorpe–Ziegler cyclization/regio-selective elimination of a –COR group, affording the desired products in moderate to good yields. The sequence of the leaving reactivity of –COR groups was determined and a possible mechanism was proposed.
Keywords
3-Dicarbonyl compounds , NBS , Sequential one-pot synthesis , Thorpe–Ziegler cyclization , Multifunctionalized thiazoles and thiophenes , 1
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1887487
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