Author/Authors :
Petri، نويسنده , , Andreas and Seidelmann، نويسنده , , Oliver and Eilitz، نويسنده , , Uwe and Leكmann، نويسنده , , Frank and Reiكmann، نويسنده , , Stefan and Wendisch، نويسنده , , Volkmar and Gutnov، نويسنده , , Andrey، نويسنده ,
Abstract :
Asymmetric conjugate addition of arylboronic acids to 2-nitroacrylamide in the presence of cationic palladium–Chiraphos complex proceeds with high yield and enantioselectivity (73–89% ee) using as low as 0.05–0.25 mol % of the catalyst. The adducts can be smoothly transformed into the corresponding β2-homophenylglycines in two simple steps.
Keywords :
Asymmetric Michael addition , Arylboronic acids , Nitroalkenes , Pd-catalysis , ?2-Amino acids
