Title of article :
A novel and effective approach to 4-fluoropyrimidines
Author/Authors :
Kseniya N. Sedenkova، نويسنده , , Kseniya N. and Averina، نويسنده , , Elena B. and Grishin، نويسنده , , Yuri K. and Kuznetsova، نويسنده , , Tamara S. and Zefirov، نويسنده , , Nikolay S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
A series of 4-fluoropyrimidine 1-oxides, obtained via three-component heterocyclization, was studied under various reduction conditions. An effective preparative method for the synthesis of 4-fluoropyrimidines from readily available starting materials was elaborated. 4-Fluoro-substituted tetrahydroquinazolines and tetrahydroquinazoline N-oxides were demonstrated to be highly reactive in aromatic nucleophilic substitution.
Keywords :
Aromatic nucleophilic substitution , 4-Fluoropyrimidines , Reduction , 4-Fluoropyrimidine N-oxides
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
