Title of article :
Stereoselective synthesis of revised structure of stagonolide G
Author/Authors :
Rajendra Prasad، نويسنده , , K. and Venkanna، نويسنده , , A. and Babu، نويسنده , , K. Suresh and Prasad، نويسنده , , A.R. Balavardhana Rao، نويسنده , , J. Madhusudana Rao، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
A concise total synthesis of the revised structure of stagonolide G has been achieved in 11 steps and with an overall yield of 31.7%. Key reaction sequence includes BAIB/TEMPO mediated tandem oxidation and lactonization, Lindlar’s hydrogenation, regioselective epoxide opening by an in situ generated alkynyl as nucleophile, Sharpless asymmetric dihydroxylation, and Jacobsen kinetic resolution.
Keywords :
BAIB/TEMPO oxidation , Lactonization , Jacobsen resolution , sharpless asymmetric dihydroxylation , Regioselective epoxide opening
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
