Title of article :
Synthesis of 1-haloethenamides from ynamide through halotrimethylsilane-mediated hydrohalogenation
Author/Authors :
Ohashi، نويسنده , , Kazuhiro and Mihara، نويسنده , , Shigenori and Sato، نويسنده , , Akihiro H. and Ide، نويسنده , , Masataka and Iwasawa، نويسنده , , Tetsuo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
A convenient synthesis of 1-haloethenamides has been achieved by utilizing halotrimethylsilane (TMSX, X = Cl, Br, I) and water. Halotrimethylsilane in 1 M CH2Cl2 solution functions as a halogen source of the in situ generated HX, and the HX added to the terminal triple bonds of ynamides in Markovnikov fashion.
Keywords :
1-Haloethenamide , exo-Methylene , Vinyl halide , Hydrohalogenation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
