Author/Authors :
Rasapalli، نويسنده , , Sivappa and Jarugumilli، نويسنده , , Gopalakrishna and Yarrapothu، نويسنده , , Gangadhara Rao and Ijaz، نويسنده , , Hamza and Golen، نويسنده , , James A. and Williard، نويسنده , , Paul G.، نويسنده ,
Abstract :
The western segment of hygrocins A–B has been synthesized through the coupling of a chiral C5–C13 synthon with the sterically demanding hexasubstituted naphthalenic core. The C5–C13 chiral fragment has been assembled via a stereoselective Johnson orthoester rearrangement of an optically pure allylic alcohol derived from d-glucose. Our studies lay the platform for the determination of the absolute configuration of the unassigned C8-stereocenter of the title compounds in addition to the completion of the total synthesis of the unique ansamacrolides hygrocins A and B.
Keywords :
Non-biomimetic , naphthoquinone , Ansamycins , Divergolides , Claisen rearrangement
