Author/Authors :
Pereira، نويسنده , , Elisabeth and Youssef، نويسنده , , Ali and El-Ghozzi، نويسنده , , Malika and Avignant، نويسنده , , Daniel J. Bain، نويسنده , , Jennifer and Prudhomme، نويسنده , , Michelle and Anizon، نويسنده , , Fabrice and Moreau، نويسنده , , Pascale، نويسنده ,
Abstract :
Two dipyrrolo[3,4-a:3,4-c]carbazole stereoisomers were unexpectedly obtained by Diels–Alder dimerization of 3-indolylmaleimide. Three dimensional structures of both stereoisomers were confirmed by X-ray analysis. Moreover compound 4 inhibits protein kinases in vitro, especially Pim-3, in the sub-micromolar range.
Keywords :
4-a:3 , cycloaddition , In vitro kinase inhibition , 4-c]carbazole , Diels–Alder reaction
