Author/Authors :
Gao، نويسنده , , Fei-Yan Deng، نويسنده , , Xiang-Jun and Tang، نويسنده , , Yu and Tang، نويسنده , , Jin-Peng and Yang، نويسنده , , Jun and Zhang، نويسنده , , Yuan-Ming، نويسنده ,
Abstract :
An efficient one-pot route to synthesize tertiary alcohol compounds using Barbier–Grignard reaction of unactivated alkyl or aryl bromides with ester in THF at 65 °C catalyzed by CuO has been developed and systematically investigated. A wide range of substituted tertiary alcohol compounds were obtained in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O-group is discussed.
Keywords :
Ester , Grignard reagent , tertiary alcohol , Synthesis
