Title of article
Synthesis and cell transfection properties of cationic uracil-morpholino tetramer
Author/Authors
Paul، نويسنده , , Sibasish and Pattanayak، نويسنده , , Sankha and Sinha، نويسنده , , Surajit، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
1072
To page
1076
Abstract
Synthesis and cell transfection properties of guanidinium-functionalized uracil morpholino tetramer have been reported for the first time. Due to the basic nature of guanidinium groups they remain protonated under physiological conditions. Such cationic tetramer exhibits efficient cellular uptake properties as visualized by microscopy imaging using fluorescent dye BODIPY. 7′-End of this morpholino tetramer was functionalized with an azide group for conjugation with various types of biomolecules or drugs for cellular delivery.
Keywords
Fluorescent imaging , Cationic morpholino , cell transfection , nucleosides , Uracil morpholino
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888111
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