Transition-metal-catalyzed ketone-directed ortho-C–H functionalization reactions

In the past 20 years, organic chemists have made significant contributions to the development of transition-metal-catalyzed ketone-directed ortho-C–H functionalization. These include Ru, Rh, Pd, and Ir-catalyzed ketone-directed C–C and C-heteroatom (O, N, Cl, Br, I) bond forming reactions. This article summarizes the developments of Ru, Rh, Pd, and Ir-catalyzed ketone-directed ortho-C–H functionalization reactions in the past two decades.