Title of article
Azo-coupling of pyrazole-3(5)-diazonium chlorides with cyanothioacetamide: a convenient synthesis of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides
Author/Authors
Ledenyova، نويسنده , , Irina V. and Didenko، نويسنده , , Vitaly V. and Dotsenko، نويسنده , , Victor V. and Shikhaliev، نويسنده , , Khidmet S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
1239
To page
1242
Abstract
Cyanothioacetamide reacts with pyrazole-3(5)-diazonium chlorides to afford pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides 5. The latter can be oxidized with H2O2 to give either pyrazolo[5,1-c][1,2,4]triazine-3-carboxamides or 1,2,4-thiadiazole derivatives, depending on the reaction conditions. The Hantzsch-type reaction of thioamides 5 with α-bromo ketones leads to 3-(thiazol-2-yl)pyrazolo[5,1-c][1,2,4]triazines.
Keywords
2 , 4]triazines , Oxidation of thioamides , Azo-coupling , Cyanothioacetamide , Hantzsch thiazole synthesis , Pyrazole-3(5)-diazonium salts
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888177
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