Author/Authors :
Mortimer، نويسنده , , Danny and Whiting، نويسنده , , Matthew and Harrity، نويسنده , , Joseph P.A. and Jones، نويسنده , , Simon and Coldham، نويسنده , , Iain، نويسنده ,
Abstract :
Lewis acid mediated intramolecular Mannich reaction between an azocinone and a 3-formylindole was investigated as part of a study towards the synthesis of actinophyllic acid. The intramolecular Mannich reaction resulted in a single diastereomer of the 1-azabicyclo[4.2.1]nonan-5-one core framework, although single crystal X-ray structure analysis revealed that this had the undesired stereochemistry in comparison with the natural product.
Keywords :
Mannich , indole , Actinophyllic acid , Azocinone
