Author/Authors :
Jin، نويسنده , , Yifeng and Khadka، نويسنده , , Daulat Bikram and Yang، نويسنده , , Su Hui and Zhao، نويسنده , , Chao and Cho، نويسنده , , Won-Jea Cho، نويسنده ,
Abstract :
5-Oxaprotoberberinones and 5-oxaprotoberberinium were synthesized as bioisosteres of protoberberines. 5-Oxaprotoberberinones were prepared by linking phenol with the isoquinolone ring of 3-phenolisoquinolones by methyleneoxy bridge, while the quaternary 5-oxaprotoberberinium salt was synthesized by reduction and oxidation of the lactam moiety of 5-oxaprotoberberinone.
Keywords :
Bioisostere , 5-Oxaprotoberberinium , Protoberberine , 5-Oxaprotberberin-8-one
