Title of article
High yield synthesis of d-phenylglycine and its derivatives by nitrilase mediated dynamic kinetic resolution in aqueous-1-octanol biphasic system
Author/Authors
Qiu، نويسنده , , Jian and Su، نويسنده , , Erzheng and Wang، نويسنده , , Wei and Wei، نويسنده , , Dongzhi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
1448
To page
1451
Abstract
A strategy of nitrilase mediated dynamic kinetic resolution toward the synthesis of d-phenylglycine was developed, using aqueous-1-octanol biphasic system. Due to the efficient suppression of the decomposition of phenylglycinonitrile, a maximum yield of 81% is obtained. This result indicates that the nitrilase mediated dynamic kinetic resolution is a promising method toward the synthesis of d-phenylglycine and its derivatives.
Keywords
Nitrilase , dynamic kinetic resolution , d-Phenylglycine , Biphasic system
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888259
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