A green-chemistry approach for the efficient synthesis of triazolo benzoxazepines or triazolo benzodiazepines in aqueous micellar system

A convenient route for the synthesis of triazole fused benzoxazepines or benzodiazepines in aqueous micellar medium has been described. The two step one-pot synthesis involves Sonogashira reaction of prop-2-ynyl 2-azidobenzoates and aryl iodides followed by intramolecular azide–alkyne cyclization using Pd(CH3CN)2Cl2 as catalyst and ethanedial,1,2-bis(2-methyl-2-phenylhydrazone) as ligand, under atmospheric condition. The method excludes the use of copper salts as catalyst as well as hazardous organic solvents.