Title of article
I2–DMSO catalyzed synthesis of 1,2,2-triarylethanones via dual C–H activation of aryl methyl ketones
Author/Authors
Raghavender Reddy، نويسنده , , M. and Nageswara Rao، نويسنده , , N. and Ramakrishna، نويسنده , , K. and Meshram، نويسنده , , H.M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
1898
To page
1901
Abstract
An I2–DMSO promoted domino protocol was developed for the synthesis of 1,2,2-triarylethanones from readily available aromatic methyl ketones and methoxybenzenes. The 1,2,2-triarylethanones are important precursors for the synthesis of Tamoxifen and Droloxifene. The use of mild reaction conditions, high yield, and single step synthesis are the advantages of the present protocol.
Keywords
DMSO , Kornblum oxidation , 1 , 2 , 2-Triarylethanones , acetophenone , iodine , Friedel–Crafts reaction
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888584
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