Author/Authors :
Zou، نويسنده , , Yuan and Zhu، نويسنده , , Fu-Lin and Duan، نويسنده , , Zheng-Chao and Wang، نويسنده , , Yahui and Zhang، نويسنده , , De-Yang and Cao، نويسنده , , Zhong and Zheng، نويسنده , , Zhuo and Hu، نويسنده , , Xiang-Ping، نويسنده ,
Abstract :
A copper-catalyzed asymmetric propargylic amination with a chiral ketimine P,N,N-ligand that proceeds via decarboxylation of propargyl carbamates has been developed. The reaction can be performed under the mild condition for a broad range of substrates, providing the corresponding propargylic amines in high yields and with up to 97% ee. This reaction represents a new and facile access to optically active propargylic amines.
Keywords :
Propargylic amination , Decarboxylation , Copper , Propargyl carbamate , Asymmetric catalysis
