Author/Authors :
Li، نويسنده , , Yu and Guo، نويسنده , , Qi and Li، نويسنده , , Xuefei and Zhang، نويسنده , , Hua and Yu، نويسنده , , Fanghua and Yu، نويسنده , , Weijiang and Xia، نويسنده , , Guiquan and Fu، نويسنده , , Mingyang and Yang، نويسنده , , Zhigang and Jiang، نويسنده , , Zhong-Xing، نويسنده ,
Abstract :
Mono-dispersed poly(ethylene glycols) (PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based solid-phase extractions were successfully employed to simplify the purifications. This synthesis provided an easy access to valuable mono-dispersed PEGs and related molecules for biomedical application on multi-gram scales.
Keywords :
Solid-phase extraction , Mono-dispersed PEGs , Fluorous Chemistry , Fluorinated surfactant
