Title of article :
Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging
Author/Authors :
Wang، نويسنده , , Xiaolei and Emoto، نويسنده , , Miho and Sugimoto، نويسنده , , Atsushi and Miyake، نويسنده , , Yusuke and Itto، نويسنده , , Kaori and Amasaka، نويسنده , , Mitsuo and Xu، نويسنده , , Shu and Hirata، نويسنده , , Hiroshi and Fujii، نويسنده , , Hirotada and Arimoto، نويسنده , , Hirokazu، نويسنده ,
Abstract :
A scalable synthetic route for 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide (15N-TEEPONE) is described. This 15N-labeled nitroxide is suitable for electron paramagnetic resonance imaging of brain, and its higher sensitivity compared with that of its 14N-counterpart is an important advantage of the labeled derivative.
Keywords :
15N-labeling , EPR imaging , Synthesis , Nitroxide radical
