Title of article
An improved palladium(II)-catalyzed method for the synthesis of aryl ketones from aryl carboxylic acids and organonitriles
Author/Authors
Axelsson، نويسنده , , Linda and Veron، نويسنده , , Jean-Baptiste and Sنvmarker، نويسنده , , Jonas and Lindh، نويسنده , , Jonas and Odell، نويسنده , , Luke R. and Larhed، نويسنده , , Mats، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
2376
To page
2380
Abstract
A palladium(II)-catalyzed decarboxylative protocol for the synthesis of aryl ketones has been developed. The addition of TFA was shown to improve the reaction yield and employing THF as solvent enabled the use of solid nitriles and in only a small excess. Using this method, five different benzoic acids reacted with a wide range of nitriles to produce 29 diverse (hetero)aryl ketone derivatives in up to 94% yield.
Keywords
Decarboxylation , Flow chemistry , Aryl ketone , Nitrile , PALLADIUM
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888920
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