Title of article :
Design and synthesis of azobenzene template based sulfonamide for capture of HCAII: dependence of efficiency on E–Z geometry
Author/Authors :
Addy، نويسنده , , Partha Sarathi and Saha، نويسنده , , Baisakhee and Panja، نويسنده , , Arpita and Das، نويسنده , , Amit Kumar and Basak، نويسنده , , Amit، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
We report the synthesis of azobenzene template based sulfonamides 1 and 2 for capture of Human Carbonic Anhydrase II (HCAII). Out of these, 1 showed successful capturing of the protein, only when it is photo-isomerized to the Z form thus demonstrating the importance of spatial proximity of the reactive and selective functionalities.
Keywords :
MALDI , Capture , Human Carbonic Anhydrase , Photoisomerization , azobenzene , Protein
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
