Author/Authors :
Kumar، نويسنده , , Yogesh and Kuila، نويسنده , , Bilash and Mahajan، نويسنده , , Dinesh Kumar Singh and Vinay Kumar Singh، نويسنده , , Prabhpreet and Mohapatra، نويسنده , , Balaram and Bhargava، نويسنده , , Gaurav، نويسنده ,
Abstract :
A metal-free diastereoselective synthesis of novel 4-halo-3,6-di-aryl-2,6-diaza-bicyclo[3.2.0]heptan-7-one by intramolecular endo-trig haloamination of 3-amino-2-azetidinone is reported. The amidiolytic ring opening of diaza-bicyclo[3.2.0]heptan-7-one with sodium methoxide provides an easy access to previously unknown 4-halo-3-aryl amino-pyrrolidine-2-carboxylic acid methyl esters in good yields.
Keywords :
Pyrrolidine ester , 3-Amino-lactam , Halocyclization , 2
