Author/Authors :
Chen، نويسنده , , Yiqun and Chen، نويسنده , , Chen-Chen and He، نويسنده , , Yao and Yu، نويسنده , , Mu and Xu، نويسنده , , Lin and Tian، نويسنده , , Chang-lin and Guo، نويسنده , , Qing-Xiang and Shi، نويسنده , , Jing and Zhang، نويسنده , , Min and Li، نويسنده , , Yi-Ming، نويسنده ,
Abstract :
Cyclic peptide trypsin inhibitor SFTI-1 was synthesized via intramolecular ligation of a linear peptide hydrazide with high yield. This cyclization strategy did not cause epimerization at the C-terminal Arg residue. CD spectrum and NMR spectroscopy analysis demonstrated that well-folded SFTI-1 could be obtained via standard oxidative folding process. Thus, we present a simple and cost-efficient strategy for the synthesis of SFTI-1.
Keywords :
Peptide hydrazides , SFTI-1 , Cyclic peptides , Protein chemical synthesis
