Author/Authors :
He، نويسنده , , Ping and Wang، نويسنده , , Xiangfen and Guo، نويسنده , , Xiujie and Ji، نويسنده , , Yannan and Zhou، نويسنده , , Chuanqi and Shen، نويسنده , , Shigang and Hu، نويسنده , , Dongbao and Yang، نويسنده , , Xiaolong and Luo، نويسنده , , Duqiang and Dukor، نويسنده , , Rina and Zhu، نويسنده , , Huajie، نويسنده ,
Abstract :
Bioactive natural product (+)-schizandrin was assigned as (7S,8S) using NMR. Recently, we obtained (+)-schizandrin from TCM Schisandra sphenanthera Rehd. et Wils. Its planar structure was well established using NMR and HR-MS including the reported references. Its absolute configuration is assigned using vibrational circular dichroism (VCD). By careful VCD investigation of (7S,8S) and (7S,8R) using B3LYP/6-311+G(d) methods, absolute configuration of (+)-schizandrin is assigned as (7S,8R). Electronic circular dichroism (ECD) was used for the discussion too and it gave the same conclusion.
Keywords :
Schizandrin , absolute configuration , VCD , ECD
