Title of article
An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles
Author/Authors
Raghunadh K Bhattar، نويسنده , , Akula and Meruva، نويسنده , , Suresh Babu and Mekala، نويسنده , , Ramamohan and Raghavendra Rao، نويسنده , , K. and Krishna، نويسنده , , Thalishetti and Gangadhara Chary، نويسنده , , R. and Vaikunta Rao، نويسنده , , L. and Syam Kumar، نويسنده , , U.K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
2986
To page
2990
Abstract
An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.
Keywords
pyrazoles , multicomponent reaction , Michael addition , Cu catalyst and Ullmann cross-coupling reaction
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889409
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