Author/Authors :
Raghunadh K Bhattar، نويسنده , , Akula and Meruva، نويسنده , , Suresh Babu and Mekala، نويسنده , , Ramamohan and Raghavendra Rao، نويسنده , , K. and Krishna، نويسنده , , Thalishetti and Gangadhara Chary، نويسنده , , R. and Vaikunta Rao، نويسنده , , L. and Syam Kumar، نويسنده , , U.K.، نويسنده ,
Abstract :
An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.
Keywords :
pyrazoles , multicomponent reaction , Michael addition , Cu catalyst and Ullmann cross-coupling reaction
