Title of article :
Genetic profile identification in clinically localized prostate carcinoma
Author/Authors :
Gallucci، نويسنده , , Michele and Merola، نويسنده , , Roberta and Leonardo، نويسنده , , Costantino and De Carli، نويسنده , , Piero and Farsetti، نويسنده , , Antonella and Sentinelli، نويسنده , , Steno and Sperduti، نويسنده , , Isabella and Mottolese، نويسنده , , Marcella and Carlini، نويسنده , , Paolo and Vico، نويسنده , , Erika and Simone، نويسنده , , Giuseppe and Cianciulli، نويسنده , , AnnaMaria، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
7
From page :
502
To page :
508
Abstract :
Purpose firm our previously obtained results, we genetically characterized prostate cancer from patients undergo radical prostatectomy in a retrospective study. als and methods ogical sections were evaluated for 106 patients treated with surgery from 1991 to 2004. With fluorescence in situ hybridization (FISH) method, the status of LPL (8p22), c-MYC (8q24) genes and 7, 8, X chromosomes was evaluated. s somes 7, 8, X aneusomy was demonstrated in 91.5%, 78.3%, and 51.9% of the samples, respectively, whereas LPL deletion and MYC amplification were found in 76.0% and 1.6%. A genetic profile was considered as unfavorable when at least two aneusomic chromosomes and one altered gene were present. Tumors with an adverse genetic profile were more frequently present in patients with higher stages (P = 0.02), biochemical/clinical progression (P = 0.03), and Gleason grade 4 + 3 (P = 0.02). Multiple correspondence analysis identified one tumor group characterized by chromosome 8 aneusomy, X polysomy, LPL gene deletion, Gleason > 7 and 4 + 3 associated with progression. sions s study, we recognized the predictive power of previously identified cytogenetic profiles. Assessment of genetic set may characterize each patient and have influence on postoperative therapeutic strategies.
Keywords :
prostate cancer , Cancer genetics , Chromosomal abnormalities , Prognostic studies
Journal title :
Urologic Oncology
Serial Year :
2009
Journal title :
Urologic Oncology
Record number :
1889427
Link To Document :
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