Margin control in open radical prostatectomy: What are the real outcomes?

The complete surgical removal of the prostate gland remains a technically challenging procedure utilizing any surgical technique. As with laparoscopic techniques, open radical retropubic prostatectomy techniques have been modified and continue to evolve but biological risk factors influence outcomes as well. A positive surgical margin, regardless of number or location, is an independent predictor of not only disease recurrence but also for receiving secondary treatment. Further research is needed to examine methods to continue to improve outcomes. Follow-up and possible adjuvant therapy needs to be individualized as the optimal timing and treatment modality continue to evolve.