Author/Authors :
Bi، نويسنده , , Bo and Ding، نويسنده , , Yuyang and Lou، نويسنده , , Qinxin and Hu، نويسنده , , Wenhui and Chan، نويسنده , , Albert S.C. and Song، نويسنده , , Hongrui and Zhao، نويسنده , , Junling، نويسنده ,
Abstract :
A highly enantioselective domino reaction of α,β-unsaturated aldehydes and 4-acetyl-5-oxohexanal catalyzed by a chiral secondary amine catalyst has been developed, providing an efficient synthetic approach for the synthesis of densely functionalized chiral cyclohexene derivatives with high yields (up to 96%) and enantioselectivities (up to 97% ee) under mild conditions.
Keywords :
organocatalytic , Domino reaction , Enantioselectivity , cyclohexenes
