Author/Authors :
Shao، نويسنده , , Li-Dong and Xu، نويسنده , , Jun and Gao، نويسنده , , Xiu and He، نويسنده , , Juan and Zhao، نويسنده , , Yu and Peng، نويسنده , , Li-Yan and Luo، نويسنده , , Huai-Rong and Xia، نويسنده , , Chengfeng and Zhao، نويسنده , , Qin-Shi، نويسنده ,
Abstract :
Intramolecular hetero-DA reaction and unexpected retro-aldol like ring opening reaction were performed. As a result, six derivatives with different skeletons of vibsane-type diterpenoids were synthesized from vibsanin B within three steps. Moreover, compounds 2, 3, and 6 enhanced the neurite outgrowth of NGF-mediated PC12 cells.
Keywords :
Intramolecular hetero-DA reaction , Retro-aldol like ring opening reaction , Vibsanin B , Neurite outgrowth promoting
