Author/Authors :
Metwaly، نويسنده , , Ahmed M. and Fronczek، نويسنده , , Frank R. and Ma، نويسنده , , Guoyi and Kadry، نويسنده , , Hazem A. and El-Hela، نويسنده , , Atef A. and Mohammad، نويسنده , , Abd-Elsalam I. and Cutler، نويسنده , , Stephen J. and Ross، نويسنده , , Samir A.، نويسنده ,
Abstract :
Four new (1–4) and two known (5 and 6) α-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3), 4-methoxy-6-methyl-5-(3-oxobutyl)-2H-pyran-2-one (4), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5), and 5-[(2E)-but-2-en-1-yl]-4-methoxy-6-methyl-2H-pyran-2-one (6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 μM and against K562 cells with IC50 values of 4.5 and 1.5 μM, respectively.
Keywords :
Antileukemic , endophytic fungi , Alternaria phragmospora , ?-Pyrone derivatives
