New simple primary amine–thiourea organocatalysts and their application in asymmetric conjugate addition

A kind of simple primary amine–thiourea organocatalysts was developed. And their application in asymmetric conjugate addition of ketone to nitroalkene was investigated. In the presence of the new primary amine–thiourea, the conjugate addition of ketone to nitroalkene proceeded smoothly to afford the 1,4-adducts in high yields with good enantioselectivities.