Author/Authors :
Blades، نويسنده , , Kevin and Demeritt، نويسنده , , Julie and Fillery، نويسنده , , Shaun and Foote، نويسنده , , Kevin M. and Greenwood، نويسنده , , Ryan and Gregson، نويسنده , , Clare and Hassall، نويسنده , , Lorraine A. and McGuire، نويسنده , , Thomas M. and Pike، نويسنده , , Kurt G. and Williams، نويسنده , , Emma، نويسنده ,
Abstract :
Two novel synthetic strategies that allow rapid diversification of the sulfone moiety in sulfonylmethyl pyrimidines, a class of compounds with a wide range of biological activity, which are of interest in a wide variety of drug discovery programmes, are described.
Keywords :
Sulfone , mTOR , pyrimidines , ATR
