Author/Authors :
Erdmann، نويسنده , , Alexandre and Halby، نويسنده , , Ludovic and Cantagrel، نويسنده , , Frédéric and Sautel، نويسنده , , François and Massiot، نويسنده , , Georges and Arimondo، نويسنده , , Paola B.، نويسنده ,
Abstract :
We report an alternative synthetic approach to annulated diaminopyrimidines based on a one-pot process, in which a Thorpe–Ziegler cyclization of a dinitrile is followed by in situ reaction with a cyanamide under highly concentrated and basic conditions. The total reaction can be carried out as fast as 30 min. The reaction mechanism is discussed. This one-pot synthetic route is universally applicable to a large variety of cyanamides and dinitriles, even natural products, to afford complex annulated diaminopyrimidines.
Keywords :
Annulated diaminopyrimidines , one-pot reaction , Cyanamides , Quinazolones
