Author/Authors :
Waterman، نويسنده , , Carrie and Calcul، نويسنده , , Laurent and Mutka، نويسنده , , Tina and Kyle، نويسنده , , Dennis E. and Pearce، نويسنده , , Cedric J. and Baker، نويسنده , , Bill J.، نويسنده ,
Abstract :
Antimalarial screening of diverse fungal samples resulted in the isolation and identification of a new sesquiterpene, trichothecinol D (1), which exhibited potent in vitro activity against Plasmodium falciparum with a 200-fold selectivity for parasite versus mammalian cytotoxicity. Trichothecinol D was obtained by bioassay-guided fractionation of two hyphomycete species. Its chemical characterization was performed by detailed NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of trichothecinol D was determined by X-ray crystallography.
Keywords :
hyphomycetes , high-throughput screening , antimalarial , sesquiterpene , Trichothecinol D
