Title of article
Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.
Author/Authors
Iwasaki، نويسنده , , Arihiro and Ohno، نويسنده , , Osamu and Sumimoto، نويسنده , , Shinpei and Suda، نويسنده , , Shoichiro and Suenaga، نويسنده , , Kiyotake، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
4126
To page
4128
Abstract
Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.
Keywords
depsipeptide , Maedamide , Marine cyanobacteria , Lyngbya , Chymotrypsin inhibitor
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890151
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